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KMID : 0939920020340030205
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대한암학회지
2002 Volume.34 No. 3 p.205 ~ p.211
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Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk
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Dae Hee Kang/Sook Un Kim
Kyoung Mu Lee/Sue Kyung Park/Keun Young Yoo/Dong Young Noh/Kook Jin Choe/Se Hyun Ahn/Dae Hee Kang
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Abstract
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Purpose: To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea.
MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.
Results: No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).
Conclusion: Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.
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KEYWORD
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Breast neoplasm, Genetic polymorphism, Glutathione S-transferase,
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